An antagonist of mGluR7

XAP044 – 10 mg

Brand:
Cayman
CAS:
196928-50-4
Storage:
-20
UN-No:
Non-Hazardous - /

XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM.{30926} This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.{30926}  

 

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Description

An antagonist of mGluR7, inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM; demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests

Formal name: 7-hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 380.1

CAS: 196928-50-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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