A positive modulator of the Wnt/β-catenin pathway

HLY78 – 1 mg

Brand:
Cayman
CAS:
854847-61-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{14336,13185,17947} HLY78 is a positive modulator of the Wnt/β-catenin pathway, as it augments Wnt-mediated signaling in cells at concentrations of 5 to 20 µM.{30791} It has no significant effect alone, and it does not affect LiCl-stimulated β-catenin signaling. A biotinylated form of HLY78 binds Axin at its DIX domain, which is thought to potentiate Axin-LRP6 association.{30791} HLY78 activates Wnt signaling in vivo, altering Wnt-dependent gene expression and embryonic development in zebrafish.{30791}  

 

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Description

A positive modulator of the Wnt/β-catenin pathway, as it augments Wnt-mediated signaling in cells at concentrations of 5 to 20 µM; active in vivo, altering Wnt-dependent gene expression and embryonic development in zebrafish

Formal name: 4-​ethyl-​5,​6-​dihydro-​5-​methyl-[1,​3]​dioxolo[4,​5-​j]​phenanthridine

Synonyms: 

Molecular weight: 267.3

CAS: 854847-61-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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