A RARβ agonist

BMS 453 – 5 mg

Brand:
Cayman
CAS:
166977-43-1
Storage:
-20
UN-No:
Non-Hazardous - /

Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.{30780} It has been shown to inhibit the proliferation of normal breast cells via the induction of TGF-β activity, causing G1 arrest.{30782} BMS 453 binding to RARα and RARγ can induce a transrepression of phorbol ester-induced AP-1 activity (IC50s = ~0.1 nM in HeLa and MCSF-7 cells), which also correlates with reduced cell proliferation.{30780} BM 453 has been used to trigger the differentiation of mouse embryonic stem cells (mES) in a study of RARβ-induced mES cell adipogenesis.{30781}  

 

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Description

A RARβ agonist, RARα/γ antagonist that inhibit the proliferation of normal breast cells via the induction of TGF-β activity, causing G1 arrest; used to trigger the differentiation of mouse embryonic stem cells

Formal name: 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl], benzoic acid

Synonyms:  BMS 189453

Molecular weight: 380.5

CAS: 166977-43-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cell Biology|Stem Cell Research|Differentiation

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