A selective RARγ agonist (Kds = 150

CD1530 – 1 mg

Brand:
Cayman
CAS:
107430-66-0
Storage:
-20
UN-No:
Non-Hazardous - /

CD1530 is a selective retinoic acid receptor (RARγ) agonist (Kds = 150, 1,500, and 2,750 nM for RARγ, RARβ, and RARα receptors, respectively).{24736} It demonstrates transcriptional activity at RARγ with an AC50 value of 1.8 nM.{24736} It has been used in combination with bexarotene (Item No. 11571), a retinoid X receptor agonist, to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma.{31184}  

 

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Description

A selective RARγ agonist (Kds = 150, 1,500, and 2,750 nM for RARγ, RARβ, and RARα receptors, respectively); demonstrates transcriptional activity at RARγ with an AC50 value of 1.8 nM

Formal name: 4-(6-hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)-benzoic acid

Synonyms: 

Molecular weight: 398.5

CAS: 107430-66-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs

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