Selective TXA2 receptor antagonist (Ki = 4.1 nM); inhibits U-46619-induced platelet aggregation (IC50 = 0.06 µM)

SQ 29,548 – 1 mg

Brand:
Cayman
CAS:
98672-91-4
Storage:
-20
UN-No:
Non-Hazardous - /

SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM.{8322} It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 µM.{6643} It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM.{1099} SQ 29,548 also inhibits the contraction of rat vascular smooth muscle induced by 8-iso PGF2α.{955}  

 

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Description

Selective TXA2 receptor antagonist (Ki = 4.1 nM); inhibits U-46619-induced platelet aggregation (IC50 = 0.06 µM)

Formal name: [1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid

Synonyms: 

Molecular weight: 387.5

CAS: 98672-91-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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