A stable analog of TXA2; unlike other TP receptor agonists

Carbocyclic Thromboxane A2 – 1 mg

Brand:
Cayman
CAS:
74034-56-3
Storage:
-20
UN-No:
De Minimis - 1170 / 3

CTA2 is a stable analog of TXA2. CTA2 is a potent coronary vasoconstrictor and is effective at concentrations as low as 1 nM in cat coronary arteries.{333} Unlike other vascular TP receptor agonists, CTA2 is a potent inhibitor of prostanoid-induced platelet aggregation. It inhibits arachidonic acid-induced aggregation with an IC50 value of 4-5 µM. CTA2 also exhibits selective and dose-dependent inhibition of TXB2 synthesis in rabbit platelets at concentrations between 1 and 100 µM.{333}  

 

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Description

A stable analog of TXA2; unlike other TP receptor agonists, it inhibits platelet aggregation (IC50 = 4-5 µM)

Formal name: 9α,11α-methylene-15S-hydroxy-11a-deoxy-11a-methylene-thromba-5Z,13E-dien-1-oic acid

Synonyms:  Carbocyclic TXA2|CTA2

Molecular weight: 348.5

CAS: 74034-56-3

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Thromboxanes||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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