A 7-deazahypoxanthine analog that prevents microtubule formation

CAY10701 – 1 mg

Brand:
Cayman
CAS:
1616967-52-2
Storage:
-20
UN-No:
Non-Hazardous - /

CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively).{32584} It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells.{32584} CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body weight.{32584}  

 

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Description

A 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa, MCF-7 cells, and colorectal cancer cell lines (GI50 values range from 9 to 38 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells

Formal name: 6-benzoyl-3,7-dihydro-2-(4-pentyn-1-yl)-5-phenyl-4H-pyrrolo[2,3-d]pyrimidin-4-one

Synonyms: 

Molecular weight: 381.4

CAS: 1616967-52-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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