An anthelmintic that is effective against F. hepatica

Triclabendazole – 1 g

Brand:
Cayman
CAS:
68786-66-3
Storage:
-20
UN-No:
Non-Hazardous - /

Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.{30605} In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.{30603,30604}  

 

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Description

An anthelmintic that is effective against F. hepatica, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite; demonstrates a protective role during various cellular stresses in yeast and mammalian cells

Formal name: 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole

Synonyms: 

Molecular weight: 359.7

CAS: 68786-66-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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