Retards the formation of mature amyloid β42 fibrils in a cell-based assay; enhances poly(I:C)-induced IFN-β expression

Ro 90-7501 – 25 mg

Brand:
Cayman
CAS:
293762-45-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ro 90-7501 is a bi-benzimidazole compound that was first found to retard the formation of mature amyloid β42 fibrils in a cell-based assay.{30566} Instead, extended polymeric sheets and fibrillary intermediates of amyloid β42 accumulated in response to Ro 90-7501 treatment, resulting in reduced cytotoxicity (EC50 = 2 µM).{30566} More recently, Ro 90-7501 was shown to modulate signaling in cells stimulated with polyinosinic-polycytidylic acid (poly(I:C); Item No. 16881), a toll-like receptor 3 (TLR3), and RIG-1-like receptor agonist.{30567} Ro 90-7501 (10 µM) enhanced poly(I:C)-induced IFN-β expression, decreased NF-κB activation, and amplified the suppression of vesicular stomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3.{30567}  

 

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Description

Retards the formation of mature amyloid β42 fibrils in a cell-based assay; enhances poly(I:C)-induced IFN-β expression, decreases NF-κB activation, and amplifies the suppression of vesicular stomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3

Formal name: 2′-​(4-​aminophenyl)​-[2,​5′-​bi-​1H-​benzimidazol]​-​5-​amine

Synonyms: 

Molecular weight: 340.4

CAS: 293762-45-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Viral Diseases||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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