A selective agonist of human TLR7; enhances the immunosuppressive activity of Treg cells at 0.5 to 2 µg/ml

Gardiquimod – 50 mg

Brand:
Cayman
CAS:
1020412-43-4
Storage:
-20
UN-No:
Non-Hazardous - /

Gardiquimod is an agonist of human toll-like receptor 7 (TLR7), but not human TLR8, although it activates both porcine TLR7 and TLR8.{31200} At 0.5 to 2 µg/ml, it enhances the immunosuppressive activity of T regulatory cells.{31198} Gardiquimod is effective as a mucosal adjuvant for Norwalk virus-like particles and inhibits infection of macrophages and T cells by HIV-1.{31199,31197} It inhibits proliferation and migration while inducing apoptosis in pancreatic cancer cells in vitro.{31201}  

 

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Description

A selective agonist of human TLR7; enhances the immunosuppressive activity of Treg cells at 0.5 to 2 µg/ml

Formal name: 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

Synonyms: 

Molecular weight: 313.4

CAS: 1020412-43-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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