The inactive isomer of omeprazole

(R)-Omeprazole (sodium salt) – 500 µg

Brand:
Cayman
CAS:
161796-77-6
Storage:
-20
UN-No:
Non-Hazardous - /

(R)-Omeprazole is the inactive isomer of omeprazole (Item No. 14880), a gastric proton-pump inhibitor.{18249,28643} A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxidation of the active (S)-enantiomer (esomeprazole magnesium, Item No. 17326).{30673} (R)-Omeprazole has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 8.1 µM).{30672}  

 

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Description

The inactive isomer of omeprazole, a gastric proton-pump inhibitor; its hydroxylation is mediated stereoselectively by CYP2C19

Formal name: 6-methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, monosodium salt

Synonyms: 

Molecular weight: 368.4

CAS: 161796-77-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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