A broad-spectrum anthelmintic that selectively binds the β-subunit of tubulin

Mebendazole – 25 g

Brand:
Cayman
CAS:
31431-39-7
Storage:
-20
UN-No:
Non-Hazardous - /

Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).{30626,30623} As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration.{30621,30624,30625} Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.{30622} Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.{30620}  

 

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Description

A broad-spectrum anthelmintic that selectively binds the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in parasites (IC50 = 0.19 µM for Giardia in vitro); also possesses antitumor properties, inducing apoptosis of various human carcinomas

Formal name: N-(6-benzoyl-1H-benzimidazol-2-yl)-carbamic acid, methyl ester

Synonyms:  NSC 184849|R 17635

Molecular weight: 295.3

CAS: 31431-39-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Giardiasis||Research Area|Neuroscience

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