A potent

CC-401 – 5 mg

Brand:
Cayman
CAS:
395104-30-0
Storage:
-20
UN-No:
Non-Hazardous - /

c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens.{17156} CC-401 is a potent inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM).{30558,30557} It has at least 40-fold selectivity for JNK compared with other related kinases. CC-401 is bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model.{30557} It also has been shown to decrease hepatic necrosis and apoptosis after orthotopic liver transplantation and prevent acute renal failure following ischemia/reperfusion associated with renal transplantation in rats.{30558,30556}  

 

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Description

A potent, selective inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM); bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model; decreases hepatic necrosis and apoptosis after orthotopic liver transplantation in rats

Formal name: 3-​[3-​[2-​(1-​piperidinyl)​​ethoxy]​phenyl]​-​​5-​(1H-​1,​2,​4-​​triazol-​5-​​yl)​-1H-​indazole

Synonyms: 

Molecular weight: 388.5

CAS: 395104-30-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|JNK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity

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