A cell-permeable benzoxazolo-sulfonamide compound that blocks human FBPase-1 enzymatic activity by competing at the AMP allosteric binding site (IC50 = 3.4 µM; Ki = 1.1 µM); blocks glucose production in starved rat hepatoma cells (IC50 = 6.6 µM)

Fructose-1,6-bisphosphatase-1 Inhibitor – 1 mg

Brand:
Cayman
CAS:
883973-99-7
Storage:
-20
UN-No:
Non-Hazardous - /

Fructose-1,6-bisphosphatase-1 (FBPase-1) is an enzyme that catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate, which is one of the rate-limiting steps in gluconeogenesis. Excess hepatic FBPase-1 activity contributes to hyperglycemia in patients. Thus, the development of specific FBPase-1 inhibitors is of great clinical interest for the treatment of patients with type 2 diabetes. FBPase-1 inhibitor is a cell-permeable benzoxazolo-sulfonamide compound that blocks human FBPase-1 enzymatic activity with an IC50 value of 3.4 µM (Ki = 1.1 µM) by competing at the AMP allosteric binding site.{30546,30547} It has been shown to block glucose production in rat hepatoma cells that are starved of nutrients with an IC50 value of 6.6 µM.{30546,30547}  

 

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Description

A cell-permeable benzoxazolo-sulfonamide compound that blocks human FBPase-1 enzymatic activity by competing at the AMP allosteric binding site (IC50 = 3.4 µM; Ki = 1.1 µM); blocks glucose production in starved rat hepatoma cells (IC50 = 6.6 µM)

Formal name: 2,​5-​dichloro-​N-​(5-​chloro-​2-​benzoxazolyl)​-benzenesulfonamide

Synonyms:  F1,6BPase-1 Inhibitor|FBP1 Inhibitor|FBPase-1 Inhibitor

Molecular weight: 377.6

CAS: 883973-99-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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