A cell permeable

Rp-8-bromo-PET-Cyclic GMPS (sodium salt) – 5 mg

Brand:
Cayman
CAS:
185246-32-6
Storage:
-20
UN-No:
Non-Hazardous - /

Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM).{29701,30362} It less potently inhibits protein kinase A (Ki = 11 µM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 µM).{29701,30363} In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki = 1 µM).{30362} Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.{24263}  

 

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Description

A cell permeable, competitive, and reversible inhibitor of cGKs that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM); less potently inhibits PKA (Ki = 11 µM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 µM); resistant to hydrolysis by PDE11

Formal name: 2-bromo-3,4-dihydro-3-[3,5-O-[(R)-mercaptophosphinylidene]-β-D-ribofuranosyl]-6-phenyl-9H-imidazo[1,2-a]purin-9-one, monosodium salt

Synonyms:  Rp-8-bromo-PET-cGMPS

Molecular weight: 562.3

CAS: 185246-32-6

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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