A potent activator of PKA (Ki = 30 nM) that is selective for PKA over PKG (Ki = 10 µM); resistant to degradation by cyclic nucleotide phosphodiesterases

Sp-5,6-dichloro-cBIMPS (sodium salt) – 1 mg

Brand:
Cayman
CAS:
142439-96-1
Storage:
-20
UN-No:
Non-Hazardous - /

Sp-5,6-dichloro-cBIMPS is a benzimidazole monophosphorothioate that acts as a potent activator of protein kinase A (PKA; Ki = 30 nM).{22886} It is selective for PKA over PKG (Ki = 10 µM).{22886} Sp-5,6-dichloro-cBIMPS is also resistant to degradation by cyclic nucleotide phosphodiesterases.{22886,24263} It displays good cell permeability and prevents the aggregation of platelets stimulated with thrombin (Item No. 13188).{22886}  

 

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Description

A potent activator of PKA (Ki = 30 nM) that is selective for PKA over PKG (Ki = 10 µM); resistant to degradation by cyclic nucleotide phosphodiesterases, displays good cell permeability, and prevents the aggregation of platelets stimulated with thrombin

Formal name: 5,6-dichloro-1-[3,5-O-[(S)-mercaptophosphinylidene]-β-D-ribofuranosyl]-1H-benzimidazole, monosodium salt

Synonyms:  Sp-5,6-DCI-cBIMPS

Molecular weight: 419.1

CAS: 142439-96-1

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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