A mitochondria-targeted antioxidant; accumulates in the mitochondria; MitoPBN inhibits superoxide activation of UCP1

MitoPBN – 10 mg

Brand:
Cayman
CAS:
652968-37-1
Storage:
-20
UN-No:
Non-Hazardous - /

MitoPBN is a mitochondria-targeted antioxidant.{30308} It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP (Item No. 15218). MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 µM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.  

 

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Description

A mitochondria-targeted antioxidant; accumulates in the mitochondria; MitoPBN inhibits superoxide activation of UCP1, UCP2, and UCP3 at 250 nM; traps hydroxyl radicals (IC50 = ~77 µM); traps carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria

Formal name: [4-[4-[[(1,1-dimethylethyl)oxidoimino]methyl]phenoxy]butyl]triphenyl-phosphonium, monobromide

Synonyms: 

Molecular weight: 590.5

CAS: 652968-37-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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