A mitochondria-targeted redox cycler that can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling

MitoPQ – 5 mg

Brand:
Cayman
CAS:
1821370-28-8
Storage:
-20
UN-No:
Non-Hazardous - /

MitoPQ is comprised of a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.{30305} Driven by membrane potential, it accumulates selectively in the mitochondrial matrix where it produces superoxide by redox cycling at the flavin site of complex I.{30305} Thus, MitoPQ selectively increases superoxide production within mitochondria and can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling.{30305}  

 

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Description

A mitochondria-targeted redox cycler that can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling

Formal name: 1-methyl-1′-(10-(triphenylphosphonio)decyl)-[4,4′-bipyridine]-1,1′-diium iodide

Synonyms:  ​MitoParaquat

Molecular weight: 954.5

CAS: 1821370-28-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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