A selective antagonist of EBI2 (IC50s = 11 and 15 nM for human and mouse receptors

NIBR189 – 1 mg

Brand:
Cayman
CAS:
1599432-08-2
Storage:
-20
UN-No:
Non-Hazardous - /

Epstein-Barr virus-induced G protein-coupled receptor 2 (EBI2, also known as GPR183) is an oxysterol receptor involved in B cell migration and function.{30804} NIBR189 is an antagonist of EBI2 (IC50s = 11 and 15 nM for human and mouse receptors, respectively).{30803} It is selective for EBI2 over a panel of other receptors, enzymes, and transporters. NIBR189 blocks the oxysterol-induced migration of U937 monocytic cells.{30803}  

 

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Description

A selective antagonist of EBI2 (IC50s = 11 and 15 nM for human and mouse receptors, respectively); blocks the oxysterol-induced migration of U937 monocytic cells

Formal name: 3-(4-bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2E-propen-1-one

Synonyms: 

Molecular weight: 429.3

CAS: 1599432-08-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Vasculature||Research Area|Immunology & Inflammation|Innate Immunity

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