A potent inhibitor of ALK (IC50 = 0.07 nM) that is less effective at IGF-1R and InsR (IC50s = 3.2 and 100 nM

ALK-IN-1 – 5 mg

Brand:
Cayman
CAS:
1197958-12-5
Storage:
-20
UN-No:
Non-Hazardous - /

ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).{31299} It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.{31299}  

 

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Description

A potent inhibitor of ALK (IC50 = 0.07 nM) that is less effective at IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively); drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM

Formal name: 5-​chloro-​N2-​[4-​[4-​(dimethylamino)​-​1-​piperidinyl]​-​2-​methoxyphenyl]​-​N4-​[2-​(dimethylphosphinyl)​phenyl]​-2,​4-​pyrimidinediamine

Synonyms: 

Molecular weight: 529

CAS: 1197958-12-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Activin-like Kinases (ALKs)||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ALK (Activin-like Kinase) Signaling

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