A microtubule-stabilizing agent that inhibits the growth of a variety of cancer cells both in vitro (IC50 values range from 0.97 to 21 nM) and in mice; brain penetrant and reduces neurodegeneration in aged tau transgenic mice; attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease

Epothilone D – 5 mg

Brand:
Cayman
CAS:
189453-10-9
Storage:
-20
UN-No:
Non-Hazardous - /

Epothilones are microtubule-stabilizing agents with potential anti-neoplastic actions.{19711,19714,26908} They are natural macrolides that have high potency in both taxane-sensitive and taxane-resistant models.{19714,26908} Epothilone D is a desoxy form of epothilone B (Item No. 10924) that inhibits the growth of a variety of cancer cells both in vitro (IC50 values range from 0.97 to 21 nM) and in mice.{26908,30210} Epothilone D is brain penetrant and reduces neurodegeneration in aged tau transgenic mice.{30209,30212} Effects include improved axonal transport, decreased tau neuropathology, and reduced hippocampal neuron loss.{30209,30212} Epothilone D also rescues microtubule defects and attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease.{30210}  

 

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Description

A microtubule-stabilizing agent that inhibits the growth of a variety of cancer cells both in vitro (IC50 values range from 0.97 to 21 nM) and in mice; brain penetrant and reduces neurodegeneration in aged tau transgenic mice; attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease

Formal name: (4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-oxacyclohexadec-13-ene-2,6-dione

Synonyms:  Desoxyepothilone B|NSC 73147

Molecular weight: 491.7

CAS: 189453-10-9

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Natural Products||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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