A cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL

BH3I-1 – 1 mg

Brand:
Cayman
CAS:
300817-68-9
Storage:
-20
UN-No:
Non-Hazardous - /

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains.{24784} BH3I-1 is a cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis.{30354} It inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 µM, respectively.{30356,30355} BH3I-1 enhances radiation sensitivity in non-small cell lung cancer cells.{30356}  

 

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Description

A cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis; inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 µM, respectively

Formal name: 5-[(4-bromophenyl)methylene]-a-(1-methylethyl)-4-oxo-2-thioxo-3-thiazolidineacetic acid

Synonyms: 

Molecular weight: 400.3

CAS: 300817-68-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis

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