A topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes

Bifonazole – 5 g

Brand:
Cayman
CAS:
60628-96-8
Storage:
-20
UN-No:
Non-Hazardous - /

Bifonazole is a topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria.{30284,25584} It is effective in the treatment of experimental dermatophytic and Candida in animals.{25584} Bifonazole is also a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM, IC50 = 270 nM), which catalyzes the biosynthesis of estrogens from androgens.{30283} When applied topically in animals, it demonstrates prolonged retention time in skin with minimal percutaneous absorption, thus minimizing its effect on aromatase.{25584}  

 

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Description

A topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria; a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM, IC50 = 270 nM),

Formal name: 1-([1,1′-biphenyl]-4-ylphenylmethyl)-1H-imidazole

Synonyms:  (±)-Bifonazole|BAY-h 4502

Molecular weight: 310.4

CAS: 60628-96-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Imidazoles||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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