An inhibitor of xanthine oxidase and active metabolite of allopurinol; formed by oxidation of allopurinol; binds to an enzyme-bound molybdenum cofactor that keeps xanthine oxidase in an inactive state; inhibits de novo purine and pyrimidine biosynthesis in human fibroblast cultures; inhibits the growth of L. donovani from 20-50 µg/ml

Oxipurinol – 5 g

Brand:
Cayman
CAS:
2465-59-0
Storage:
-20
UN-No:
Non-Hazardous - /

Oxipurinol is an inhibitor of xanthine oxidase and active metabolite of the xanthine oxidase inhibitor allopurinol (Item No. 10012597).{61053} Oxipurinol is formed by the oxidation of allopurinol and binds to an enzyme-bound molybdenum cofactor that keeps xanthine oxidase in an inactive state. It inhibits de novo purine and pyrimidine biosynthesis in human fibroblast cultures.{61054} Oxipurinol also inhibits the growth of L. donovani when used at concentrations ranging from 20 to 50 µg/ml.{61055}  

 

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Description

An inhibitor of xanthine oxidase and active metabolite of allopurinol; formed by oxidation of allopurinol; binds to an enzyme-bound molybdenum cofactor that keeps xanthine oxidase in an inactive state; inhibits de novo purine and pyrimidine biosynthesis in human fibroblast cultures; inhibits the growth of L. donovani from 20-50 µg/ml

Formal name: 1H-​pyrazolo[3,​4-​d]​pyrimidine-​4,​6(5H,​7H)​-​dione

Synonyms:  Alloxanthine|NSC 76239

Molecular weight: 152.1

CAS: 2465-59-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Infectious Disease|Parasitic Diseases|Leishmaniasis||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Xanthine Oxidase||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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