A cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 µM for PLAP and NSAP

L-p-Bromotetramisole (oxalate) – 25 mg

Brand:
Cayman
CAS:
62284-79-1
Storage:
-20
UN-No:
Non-Hazardous - /

Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like).{30380} L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 µM for PLAP and NSAP, respectively).{30380,30384,30383,30381} While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition.{30383} L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.{30382,30385}  

 

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Description

A cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 µM for PLAP and NSAP, respectively); also used as a tyrosine phosphatase inhibitor

Formal name: (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole, monoethanedioate

Synonyms:  (-)-p-Bromotetramisole|L-para-Bromotetramisole

Molecular weight: 373.2

CAS: 62284-79-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cell Biology|Cell Signaling

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