A central nervous system modulator that is used to experimentally induce seizures in animals; used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures

Pentylenetetrazole – 10 g

Brand:
Cayman
CAS:
54-95-5
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals.{30232} Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures.{17321,23990} PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABAA receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABAA receptor.{30231,30233}  

 

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Description

A central nervous system modulator that is used to experimentally induce seizures in animals; used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures

Formal name: 6,7,8,9-tetrahydro-5H-etrazolo[1,5-a]azepine

Synonyms:  1,5-Pentamethylenetetrazole|NSC 5729|NSC 66489|PTZ|α,β-Cyclopentamethylenetetrazole

Molecular weight: 138.2

CAS: 54-95-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

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