A cell-permeable suppressor of TSA action

ITSA1 – 10 mg

Brand:
Cayman
CAS:
200626-61-5
Storage:
-20
UN-No:
Non-Hazardous - /

Trichostatin A (TSA; Item No. 89730) is a potent, reversible inhibitor of histone deacetylase (HDAC) that inhibits HDAC1 (IC50 = 70 nM) in Jurkat cells, resulting in cell cycle arrest.{8150} ITSA1 is a cell-permeable benzotriazole amide that blocks TSA action, reducing TSA-induced acetylation of histone and tubulin in A549 cells when given at 50 µM.{30169} At the same concentration, ITSA1 also prevents TSA-mediated cell cycle arrest and apoptosis.{30169} It similarly blocks the action of the HDAC inhibitor SAHA (Item No. 10009929), preventing SAHA-induced hyperacetylation of tubulin in A549 cells.{30169} ITSA1 reduces TSA-regulated transcription in mouse embryonic stem cells and in zebrafish.{30169}  

 

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Description

A cell-permeable suppressor of TSA action, reducing TSA-induced acetylation of histone and tubulin in A549 cells when given at 50 µM; prevents TSA-mediated cell cycle arrest and apoptosis; blocks the action of the HDAC inhibitor SAHA, preventing SAHA-induced hyperacetylation of tubulin in A549 cells

Formal name: 1H-benzotriazol-1-yl(2,4-dichlorophenyl)-methanone

Synonyms: 

Molecular weight: 292.1

CAS: 200626-61-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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