A metabolite of the nucleoside reverse transcriptase inhibitor

3′-Azido-3′-deoxythymidine β-D-glucuronide (sodium salt) – 1 mg

Brand:
Cayman
CAS:
133525-01-6
Storage:
-20
UN-No:
Non-Hazardous - /

3′-Azido-3′-deoxythymidine β-D-glucuronide is a metabolite of the nucleoside reverse transcriptase inhibitor, zidovudine (Item No. 15492), formed by direct conjugation by UDP-glucuronosyltransferase 2B7.{20875} The azido group of both zidovudine and its glucuronide metabolite can be reduced to an amino group by cytochrome P450 (CYP)3A, CYP2A6, or CYP2B1, forming 3’-amino-3’-deoxythymidine (AMT) and AMT glucuronide, respectively.{30307} Several compounds, including rifampicin (Item No. 14423), valproic acid (Item No. 13033), fluconazole (Item No. 11594), and efavirenz (Item No. 14412) are known to interfere with zidovudine glucuronidation in vitro in human liver microsomes.{30307,30306} Formation of AMT, which is 5-7-fold more toxic than the parent drug, is thought to be enhanced through inhibition of zidovudine glucuronidation.{30307}  

 

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Description

A metabolite of the nucleoside reverse transcriptase inhibitor, zidovudine, formed by direct conjugation by UGT2B7

Formal name: 3′-azido-3′-deoxy-5′-O-β-D-glucopyranuronosyl-thymidine, monosodium salt

Synonyms:  AZT glucuronide|Zidovudine glucuronide

Molecular weight: 465.4

CAS: 133525-01-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Nucleoside Reverse Transcriptase Inhibitors (NRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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