Description
An S-COMT inhibitor (IC50 = 300 nM in rat liver); is selective for S-COMT over tyrosine hydroxylase, dopamine-β-hydroxylase, DOPA decarboxylase, MAO-A, and MAO-B (IC50s = >1 µM for all); inhibits liver, duodenal, and brain S-COMT (ID50s = 5, 5, and 25 mg/kg, respectively); reduces 3-OMD formation and increases serum and brain L-DOPA, dopamine, and DOPAC levels when administered in combination with L-DOPA and carbidopa from 3-30 mg/kg; reduces mechanical and cold allodynia in a rat model of spinal nerve ligation-induced neuropathy at 30 mg/kg
Formal name: 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione
Synonyms: OR-462
Molecular weight: 265.2
CAS: 116313-94-1
Purity: ≥98%
Formulation: A crystalline solid
Application||Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Neuroscience|Pain Research
