An inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells; blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells

Mitotane – 500 mg

Brand:
Cayman
CAS:
53-19-0
Storage:
-20
UN-No:
Non-Hazardous - /

Mitotane is an inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells.{30365,30364} It blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells.{30365,30364} Mitotane has anti-neoplastic actions, alone or in combination with other compounds, and suppresses cortisol synthesis, although it also has significant toxicity in the gastrointestinal tract and nervous system.{30367,30366} It is effective against adrenocortical carcinoma and Cushing’s Syndrome in clinical trials.{30366,24098}  

 

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Description

An inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells; blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells

Formal name: 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-benzene

Synonyms:  NSC 38721|o,p’-DDD

Molecular weight: 320

CAS: 53-19-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids

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