An active metabolite of adefovir dipivoxil; formed from adefovir dipivoxil by CES2; inhibits cytopathogenicity induced by HSV-1 and HSV-2 (EC50 = 7 µg/ml for both in E6SM cells)

Adefovir – 250 mg

Brand:
Cayman
CAS:
106941-25-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Adefovir is an active metabolite of the antiviral nucleoside analog adefovir dipivoxil (Item No. 28373).{56174} Adefovir is formed from adefovir dipivoxil by gastrointestinal carboxylesterase 2 (CES2).{56175} It inhibits cytopathogenicity induced by herpes simplex virus 1 (HSV-1) and HSV-2 (EC50 = 7 µg/ml for both in E6SM cells), HIV-1 and HIV-2 (EC50s = 1.8 and 2.5 µg/ml, respectively, in CEM cells), and varicella zoster virus (VZV; EC50 = 10 µg/ml in human embryonic lung fibroblasts).{56176} Adefovir (50 mg/kg, p.o.) reduces increases in lymph node viral DNA and serum IgG levels in a mouse model of AIDS induced by infection with the retroviral complex LP-BM5.{56177} It also inhibits tumor growth induced by Moloney sarcoma virus (MSV) infection in mice at the same dose.{56178}  

 

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Description

An active metabolite of adefovir dipivoxil; formed from adefovir dipivoxil by CES2; inhibits cytopathogenicity induced by HSV-1 and HSV-2 (EC50 = 7 µg/ml for both in E6SM cells), HIV-1 and HIV-2 (EC50s = 1.8 and 2.5 µg/ml, respectively, in CEM cells), and VZV (EC50 = 10 µg/ml in human embryonic lung fibroblasts); reduces increases in lymph node viral DNA and serum IgG levels in a mouse model of AIDS induced by infection with LP-BM5 at 50 mg/kg; inhibits tumor growth induced by MSV infection in mice at 50 mg/kg

Formal name: P-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-phosphonic acid

Synonyms:  GS-0393|PMEA

Molecular weight: 273.2

CAS: 106941-25-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Nucleoside Reverse Transcriptase Inhibitors (NRTIs)||Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Chicken Pox & Shingles||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Infectious Disease|Viral Diseases|HSV

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