A flavanone rutinoside found in citrus peels with antioxidant

Hesperidin – 100 g

Brand:
Cayman
CAS:
520-26-3
Storage:
-20
UN-No:
Non-Hazardous - /

Hesperidin is a flavanone rutinoside first isolated from citrus peels. It is metabolized by intestinal bacteria to an aglycone form, hesperetin (Item No. 10006084), which is thought to be more bioavailable due to reduced polarity that allows for increased cell permeability.{25344,30157} At 100 µM, hesperidin has been shown to increase the cytotoxicity of doxorubicin (Item No. 15007) on MCF-7 and HeLa cancer cells in vitro by inhibiting cell cycle progression and upregulating apoptosis.{25344} It also is reported to produce estrogenic effects, decreasing serum and hepatic lipid concentrations and reducing osteoporosis in ovariectomized rats.{25344} Hesperidin produces free radical scavenging activity in various in vitro antioxidant assays.{25344}  

 

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Description

A flavanone rutinoside found in citrus peels with antioxidant, anticancer, and estrogenic effects in in vitro and in vivo research models; increases the cytotoxicity of doxorubicin on MCF-7 and HeLa cancer cells; decreases serum and hepatic lipid concentrations and reduces osteoporosis in ovariectomized rats

Formal name: 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-,(2S)-4H-1-benzopyran-4-one

Synonyms:  Cirantin|Hesperidoside|NSC 44184

Molecular weight: 610.6

CAS: 520-26-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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