An α1-AR antagonist (Kis = 3.16

Doxazosin (mesylate) – 100 mg

Brand:
Cayman
CAS:
77883-43-3
Storage:
-20
UN-No:
Non-Hazardous - /

Doxazosin is a non-selective antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.16, 1, and 3.98 nM for α1A­-, α1B-, and α1D-ARs, respectively).{18268} It inhibits norepinephrine-induced contractions in isolated rat aorta rings and human prostate strips with pA2 values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2 = 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.  

 

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Description

An α1-AR antagonist (Kis = 3.16, 1, and 3.98 nM for α1A­-, α1B-, and α1D-ARs, respectively); inhibits norepinephrine-induced contractions in isolated rat aorta rings and human prostate strips (pA2s = 8.8 and 8.2, respectively); inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2 = 7.5 for both)

Formal name: [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)-methanone, monomethanesulfonate

Synonyms:  UK 33274-27

Molecular weight: 547.6

CAS: 77883-43-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation

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