A dual inhibitor of PKC and SPHK; inhibits PKC by binding at the regulatory phorbol-binding domain (IC50 = 24 µM); inhibits SPHK (Ki = ~5 µM); restores sensitivity to cisplatin in resistant AGScis5 cells and N87 gastric cancer cells from 0.2-6 µM

Safingol – 10 mg

Brand:
Cayman
CAS:
15639-50-6
Storage:
-20
UN-No:
Non-Hazardous - /

Safingol is the L-threo diastereomer of D-erythro-sphinganine (Item No. 10007945) and a dual inhibitor of PKC and sphingosine kinase (SPHK).{30406,24886} It inhibits PKC by binding at the regulatory phorbol-binding domain (IC50 = 24 µM).{30406} Safingol also inhibits SPHK (Ki = ~5 µM).{24886} Safingol (0.2-6 µM) restores sensitivity to cisplatin (Item No. 13119) in resistant AGScis5 cells and N87 gastric cancer cells in a concentration-dependent manner.{30405} [Matreya, LLC. Catalog No. 1807]  

 

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Description

A dual inhibitor of PKC and SPHK; inhibits PKC by binding at the regulatory phorbol-binding domain (IC50 = 24 µM); inhibits SPHK (Ki = ~5 µM); restores sensitivity to cisplatin in resistant AGScis5 cells and N87 gastric cancer cells from 0.2-6 µM

Formal name: (2S,3S)-2-amino1,3-octadecanediol

Synonyms:  L-threo-Dihydrosphingosine|L-threo-Sphinganine

Molecular weight: 301.5

CAS: 15639-50-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Lipid Kinases||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer|Cell Signaling|PKC Signaling||Research Area|Lipid Biochemistry|Sphingolipids

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