A selective agonist of β3-adrenergic receptors with Ki values of 0.43

BRL 37344 (sodium salt) – 5 mg

Brand:
Cayman
CAS:
127299-93-8
Storage:
-20
UN-No:
Non-Hazardous - /

BRL 37344 is a selective agonist of β3-adrenergic receptors with Ki values of 0.43, 9.17, and 37.9 µM for β3, β2, and β1, respectively.{25395} β3-Adrenoceptors are expressed in adipose tissue as well as endothelial and myocardial tissues.{30103} This compound has been used to explore the role of these receptors in the regulation of thermogenesis and lipolysis and to modulate cardiac function in models of cardiovascular disease.{30104} It has also been used in rodents to study the role that β3-adrenergic receptors play in regulating anxiety-like behaviors.{30102}  

 

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Description

A selective agonist of β3-adrenergic receptors with Ki values of 0.43, 9.17, and 37.9 µM for β3, β2, and β1, respectively

Formal name: rel-2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-acetic acid, monosodium salt

Synonyms:  BRL 37344A

Molecular weight: 385.8

CAS: 127299-93-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Endocrinology & Metabolism|Thermogenesis||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety

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