Description
A radioprotective agent and an active metabolite of amifostine; scavenges ABTS radicals in a cell-free assay; prevents γ-radiation-induced single- and double-stranded DNA breaks, as well as inhibits γ-radiation induced mutations at the HGPRT locus in V79-B310H lung fibroblast cells at 4 mM; reduces cis-DDP-induced mutations at the HGPRT locus in V79-B310H cells; increases survival, reduces the loss of bone marrow progenitor cells, and inhibits decreases in intestinal collagen thickness and crypt and Paneth cell density in mice exposed to total body γ-irradiation at 500 mg/kg prior to irradiation
Formal name: 2-[(3-aminopropyl)amino]-ethanethiol, dihydrochloride
Synonyms: WR 1065
Molecular weight: 207.2
CAS: 14653-77-1
Purity: ≥90%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|DNA Damage and Repair||Research Area|Cancer|Metabolism||Research Area|Cancer|Transcription Factors|p53||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Toxicology|Drug Metabolism|Drug Metabolites
