An asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates; demonstrates therapeutic activity in experimental models of organophosphate poisoning

Asoxime (chloride) – 10 mg

Brand:
Cayman
CAS:
34433-31-3
Storage:
-20
UN-No:
Non-Hazardous - /

Organophosphates inactivate acetylcholinesterase (AChE) by reacting covalently with the active center serine, thus inhibiting its action of hydrolyzing acetylcholine at central and peripheral synapses. Acetylcholine accumulation results in an over-stimulation of cholinergic receptors, which can disrupt numerous biological functions. Asoxime is an asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates.{30073} It demonstrates therapeutic activity in experimental models of organophosphate poisoning, by reactivating phosphorylated AChE that was inhibited as a result of exposure to various cytotoxic nerve agents.{30072,30071}  

 

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Description

An asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates; demonstrates therapeutic activity in experimental models of organophosphate poisoning

Formal name: 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium, dichloride

Synonyms:  HI-6

Molecular weight: 359.2

CAS: 34433-31-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Neuroscience

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