A small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA-patient fibroblasts by 50% at 18 µM; increases phosphorylation of ERK to initiate Ras-Raf-MEK signaling

Cuspin-1 – 10 mg

Brand:
Cayman
CAS:
337932-29-3
Storage:
-20
UN-No:
Non-Hazardous - /

The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA).{22324} Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 µM.{30105} Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.{30105}  

 

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Description

A small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA-patient fibroblasts by 50% at 18 µM; increases phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation

Formal name: (5-bromo-3-pyridinyl)(4-methylphenyl)-methanone

Synonyms:  Chemical Upregulator of SMN Protein-1

Molecular weight: 276.1

CAS: 337932-29-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Neuroscience|Neurodegenerative Disorders

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