A high affinity agonist of TSPO (Ki = 0.297 nM in rat whole brain) that exhibits IC50 values of 2.73 and 3.04 nM

AC-5216 – 10 mg

Brand:
Cayman
CAS:
226954-04-7
Storage:
-20
UN-No:
Non-Hazardous - /

AC-5216 is a high affinity agonist of the 18 kDa translocator protein (TSPO, previously called the peripheral benzodiazepine receptor) that exhibits a Ki value of 0.297 nM in rat whole brain and IC50 values of 2.73 and 3.04 nM, respectively, against human and rat glial TSPO.{29754} AC-5216 produces anxiolytic and antidepressant effects in various animal models, without inducing benzodiazepine-like adverse effects.{29754,29755}  

 

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Description

A high affinity agonist of TSPO (Ki = 0.297 nM in rat whole brain) that exhibits IC50 values of 2.73 and 3.04 nM, respectively, against human and rat glial TSPO; produces anxiolytic and antidepressant effects in various animal models, without inducing benzodiazepine-like adverse effects

Formal name: N-ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide

Synonyms:  Emapunil|XBD-173

Molecular weight: 401.5

CAS: 226954-04-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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