A selective PPARα agonist (EC50 = 20 µM) that has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rats and has been used clinically in the treatment of dyslipidemia

Ciprofibrate – 1 g

Brand:
Cayman
CAS:
52214-84-3
Storage:
-20
UN-No:
Non-Hazardous - /

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. Ciprofibrate activates PPARα with an EC50 value of 20 µM and only marginally affects PPARγ (EC50 = >300 µM).{8548} It has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rats and has been used clinically in the treatment of dyslipidemia.{8548,29847} Ciprofibrate reportedly stimulates cholesteryl ester transfer protein expression and improves the flow of cholesterol through the indirect reverse cholesterol transport system, preserving plasma HDL.{29848}  

 

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Description

A selective PPARα agonist (EC50 = 20 µM) that has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rats and has been used clinically in the treatment of dyslipidemia

Formal name: 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl-propanoic acid

Synonyms:  (±)-Ciprofibrate|WIN 35,833

Molecular weight: 289.2

CAS: 52214-84-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Lipids & Lipoproteins|Storage & Transport||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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