A 2-acetamidopyranoside that selectively inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM; reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis when used at 1 mg/kg in vivo

TLR4-C34 – 10 mg

Brand:
Cayman
CAS:
40592-88-9
Storage:
-20
UN-No:
Non-Hazardous - /

Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response, which typically includes increased expression of TNFα.{28195} TLR4-C34 is a 2-acetamidopyranoside that inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM.{29731,29732} It does not affect signaling through either TLR2 or TLR9. TLR4-C34, used at 1 mg/kg in vivo, also reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.{29731} It markedly decreases the basal expression of TNFα, as well as LPS-induced iNOS and TNFα expression, in intestinal tissue isolated from patients with necrotizing enterocolitis.{29731}  

 

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Description

A 2-acetamidopyranoside that selectively inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM; reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis when used at 1 mg/kg in vivo

Formal name: 1-methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside, 3,4,6-triacetate

Synonyms:  C34|TLR4-IN-C34|Toll-Like Receptor 4-C34

Molecular weight: 389.4

CAS: 40592-88-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Bacterial Diseases

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