A non-selective blocker of voltage-dependent K+-channels (Kv channels) that has greatest potency at Kv1 and Kv3 family members (IC50s = 290

4-Aminopyridine – 25 g

Brand:
Cayman
CAS:
504-24-5
Storage:
-20
UN-No:
Limited Quantity - 2671 / 6.1

4-Aminopyridine (4-AP) is a non-selective blocker of voltage-dependent K+-channels (Kv proteins in the KCN gene family). It has greatest potency at Kv1 (KCNA) and Kv3 (KCNC) family members (IC50s = 290, 590, 195, 13, 29, and 100 µM for subunits 1.1, 1.2, 1.3, 1.4, 3.1, and 3.2, respectively).{29898} 4-AP also blocks Kv2 and Kv4 subunits at millimolar concentrations.{29898} When administered orally, 4-AP has benefits against multiple sclerosis, while injection into the brain produces epileptiform activity and can be used to study seizures.{29897,29899,29900}  

 

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Description

A non-selective blocker of voltage-dependent K+-channels (Kv channels) that has greatest potency at Kv1 and Kv3 family members (IC50s = 290, 590, 195, 13, 29, and 100 µM for subunits 1.1, 1.2, 1.3, 1.4, 3.1, and 3.2, respectively); also blocks Kv2 and Kv4 subunits at millimolar concentrations

Formal name: 4-pyridinamine

Synonyms:  4-AP|BRL 34915|Dalfampridine|Fampridine|NSC 15041

Molecular weight: 94.1

CAS: 504-24-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

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