A bioactive monohydroxylated metabolite of the cholinesterase inhibitor

Hydroxytacrine (maleate) – 1 g

Brand:
Cayman
CAS:
118909-22-1
Storage:
-20
UN-No:
Non-Hazardous - /

Hydroxytacrine is a bioactive monohydroxylated metabolite of the cholinesterase inhibitor, tacrine (Item No. 70240), produced by cytochrome P450 1A-catalyzed hydroxylation.{30767} While tacrine has been used clinically in the treatment of Alzheimer’s disease, its prolonged use is associated with liver toxicity.{17054,6603} Hydroxytacrine demonstrates similar anticholinesterase activity to tacrine, yet has less acute toxicity in both animal and clinical studies of Alzheimer’s disease.{30768,30766}  

 

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Description

A bioactive monohydroxylated metabolite of the cholinesterase inhibitor, tacrine that has less acute liver toxicity than tacrine in both animal and clinical studies of Alzheimer’s disease

Formal name: 9-​amino-​1,​2,​3,​4-​tetrahydro-1-acridinol​, 2Z-butenedioate

Synonyms:  1-Hydroxytacrine|HP 029|P 83-6029A|Velnacrine

Molecular weight: 330.3

CAS: 118909-22-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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