A DPP-4 inhibitor (IC50 = 4 nM)>10

Trelagliptin – 5 mg

Brand:
Cayman
CAS:
865759-25-7
Storage:
-20
UN-No:
Non-Hazardous - /

Trelagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 4 nM).{29892} It is greater than 10,000-fold selective for DPP-4 over isopeptidases. Trelagliptin (7 mg/kg) inhibits plasma DPP-4 activity and reduces postprandial plasma insulin levels in Zucker fa/fa rats. Formulations containing trelagliptin have been used in the treatment of type 2 diabetes mellitus.  

 

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Description

A DPP-4 inhibitor (IC50 = 4 nM)>10,000-fold selective for DPP-4 over isopeptidases; inhibits plasma DPP-4 activity and reduces postprandial plasma insulin levels in Zucker fa/fa rats at 7 mg/kg

Formal name: 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-benzonitrile

Synonyms:  SYR-472

Molecular weight: 357.4

CAS: 865759-25-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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