Description
A multi-kinase inhibitor; inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ (IC50s = 1.5, 2.5, 4.2, 7, 13, and 22 nM, respectively); inhibits B-RAF, VEGFR3, FGFR, and Tie2 (IC50s = 28, 46, 202, and 311 nM, respectively); reduces tumor size in the MDA-MB-231 breast and 786-O renal cancer mouse xenograft models at 10 mg/kg; reduces tumor microvessel area and inhibits tumor growth in a panel of mouse xenograft models
Formal name: 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
Synonyms: BAY 73-4506
Molecular weight: 482.8
CAS: 755037-03-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling
