A noncompetitive

ML 141 – 5 mg

Brand:
Cayman
CAS:
71203-35-5
Storage:
-20
UN-No:
Non-Hazardous - /

Cdc42 is a member of the Rho GTPase subfamily that has roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. It cycles between a GTP-bound active state and a GDP-bound inactive state. ML 141 is a noncompetitive, allosteric inhibitor of Cdc42 (EC50 = 2.1 µM) with no inhibitory action against Rho, Ras, Rab, or Rac.{29788,29791} It also inhibits the constitutively active Cdc42 Q61L mutant (EC50 = 2.6 µM).{29788} ML 141 blocks Cdc42-dependent filopodia formation in 3T3 cells and migration of ovarian cancer cells, prevents Cdc42-regulated virus infection, and inhibits the signaling pathway of VLA-4 integrin.{29788} It is a useful tool to interrogate the role of Cdc42 intracellular signaling and cell activity.{29789,29790}  

 

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Description

A noncompetitive, allosteric inhibitor of Cdc42 (EC50 = 2.1 µM) with no inhibitory action against Rho, Ras, Rab, or Rac; also inhibits the constitutively active Cdc42 Q61L mutant (EC50 = 2.6 µM)

Formal name: 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide

Synonyms:  CID2950007

Molecular weight: 407.5

CAS: 71203-35-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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