A selective c-Met inhibitor (IC50 = 3 nM) that inhibits c-Met phosphorylation and downstream signaling in various cancer cell lines (IC50s = 6-9 nM) and at 5-15 mg/kg regresses tumors in mouse xenograft models

EMD 1214063 – 1 mg

Brand:
Cayman
CAS:
1100598-32-0
Storage:
-20
UN-No:
Non-Hazardous - /

MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. EMD 1214063 inhibits c-Met with an IC50 value of 3 nM, demonstrating at least 1,000-fold selectivity for c-Met over a panel of 242 additional kinases.{29889} It has been shown to inhibit c-Met phosphorylation and downstream signaling in various cancer cell lines (IC50s = 6-9 nM) and, at 5-15 mg/kg, to regress tumors in mouse xenograft models.{29889}  

 

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Description

A selective c-Met inhibitor (IC50 = 3 nM) that inhibits c-Met phosphorylation and downstream signaling in various cancer cell lines (IC50s = 6-9 nM) and at 5-15 mg/kg regresses tumors in mouse xenograft models

Formal name: 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-benzonitrile

Synonyms:  MSC2156119|Tepotinib

Molecular weight: 492.6

CAS: 1100598-32-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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