A selective inhibitor of PARP3 (IC50 = 0.89 µM); cell permeable and elicits PARP3-specific effects at submicromolar concentrations

ME0328 – 10 mg

Brand:
Cayman
CAS:
1445251-22-8
Storage:
-20
UN-No:
Non-Hazardous - /

The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.{22577,22591} ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.{29869} It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.{29869}  

 

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Description

A selective inhibitor of PARP3 (IC50 = 0.89 µM); cell permeable and elicits PARP3-specific effects at submicromolar concentrations

Formal name: 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

Synonyms: 

Molecular weight: 321.4

CAS: 1445251-22-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|DNA Damage and Repair||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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