A cationic porphyrin that intercalates into and stabilizes G-quadruplexes; inhibits telomerase activity (IC50 ≤ 50 µM)

TMPyP4 (tosylate) – 250 mg

Brand:
Cayman
CAS:
36951-72-1
Storage:
-20
UN-No:
Non-Hazardous - /

TMPyP4 is a cationic porphyrin that intercalates into and stabilizes G-quadruplexes, which are formed by DNA and RNA sequences composed of blocks of guanine residues.{29692} In this way, TMPyP4 inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo.{29694,29695,29696} TMPyP4 also inhibits acetylcholinesterase at doses of 0.1 to 1.0 mM.{29693}  

 

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Description

A cationic porphyrin that intercalates into and stabilizes G-quadruplexes; inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo

Formal name: 4,4′,4”,4”’-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[1-methyl-pyridinium], 4-methylbenzenesulfonate (1:4)

Synonyms:  TMP-1363|TMPyP4 4-methylbenzenesulfonate

Molecular weight: 1,363.60

CAS: 36951-72-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Cancer|Cell Migration & Metastasis

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