The active metabolite of oxcarbazepine that demonstrates anticonvulsant efficacy by inhibiting both voltage-gated Na+ and Ca2+ channels

10,11-dihydro-10-hydroxy Carbamazepine – 10 mg

Brand:
Cayman
CAS:
29331-92-8
Storage:
-20
UN-No:
Non-Hazardous - /

10,11-dihydro-10-hydroxy Carbamazepinee is the active metabolite of oxcarbazepine (Item No. 17340). Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydro-10-hydroxycarbamazepine, which then demonstrates anticonvulsant efficacy by modulating several ion channels and receptors.{25311,25313} 10,11-dihydro-10-hydroxy Carbamazepine is reported to inhibit both voltage-gated Na+ and Ca2+ channels, to potentiate voltage-gated K+ channels, to antagonize adenosine A1 receptors, to increase dopaminergic transmission, and to inhibit glutamate release.{25311}  

 

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Description

The active metabolite of oxcarbazepine that demonstrates anticonvulsant efficacy by inhibiting both voltage-gated Na+ and Ca2+ channels, potentiating voltage-gated K+ channels, antagonizing adenosine A1 receptors, increasing dopaminergic transmission, and inhibiting glutamate release

Formal name: 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide

Synonyms:  ​10,11-hydroxy-10,11 Dihydrocarbamezer|BIA 2-005|GP 47779|Licarbazepine

Molecular weight: 254.3

CAS: 29331-92-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience|Seizure Disorders

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